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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

个人电脑使用周期延长,再加上智能手机和平板电脑带来的竞争,大大抑制消了消费者对PC的需求。据IDC数据显示,全球各地区的电脑出货量均连续5个季度出现下滑。
The CSI 300, which consists of 300 of the top A-shares traded on the Shanghai and Shenzhen exchanges, is down 7 per cent and will be shut for the remainder of the day.

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

contribution
10、 因为与邦德在一起很有趣,女人往往会迷上他,这在人际关系中很重要,也是很多首次约会一拍即合的秘诀。甚至派去杀他的女特工也会爱上他。研究证明,这也不奇怪,007的形象常被批成大男子主义,也许不错--但是,只能让他在女人面前的魅力有增无减。

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

From the themed collection: 我在北京棚改项目做拆迁
Open Access Perspective

Soft matter science and the COVID-19 pandemic

"这个家伙对当前情况作了利弊权衡:他有很大机会从故障电梯逃生,但是如果家庭作业没完成,他会很倒霉。"一名名为Zealshifang的用户调侃道。

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

Gender diversity is increasing among graduates working in the financial industry, according to data collected for the 2017 edition of the Financial Times ranking of masters in finance programmes.

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

Halloween is just a few days away. Which means, if you haven’t gotten your costume or decorations sorted out yet, you might want to start doing that pretty soon.
如果有什么电影能够至少在两个小时里,为美国生活中深刻的种族、代际与阶层鸿沟架起桥梁,那可能就是这部古老的《洛基》(Rocky)系列的复活影片。西尔维斯特·史泰龙(Sylvester Stallone)拖着脚步,饰演这个聪明的老教练角色,给出了他演艺生涯中或许是最松弛、最温暖的表演。迈克尔·B·乔丹饰演洛基的被保护人阿多尼斯·约翰逊(Adonis Johnson),他也是洛基一度的竞争对手和早已丧失的朋友阿波罗·奎迪(Apollo Creed)的私生子,他成了我们这个时代重要的影星。至于库格勒,这是他执导的第二部唱片,证明他是一个真正的斗士。
天文学家在2016年宣布,LIGO阵列检测到了两个黑洞碰撞所释放出来的引力波,证实了爱因斯坦广义相对论的关键部分。研究人员因这项发现而获得了诺贝尔物理学奖。但是研究人员的发现仍未结束:10月,科学家们监测到了两颗中子星的碰撞,不仅听到了碰撞造成的时空涟漪,而且还用性能强大的望远镜在光学上确认了这一事件。中子星的碰撞被认为是宇宙中所有重金属的来源,包括黄金和白银,LIGO的探测有助于验证有关宇宙化学形成的解释。
全球缓慢的经济增长并不会很大程度的拖累美国。美国的出口额虽然可能持平甚至下降,但是这将会被由于油价下降的石油进口额抵消,所以贸易赤字并不会给美国经济造成更进一步的影响。

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

我花钱太多了吗?过度消费会导致压力、混乱以及财政并发症。这也可能会随着时间的流逝变为一种危险的习惯。储蓄是一个非常棒的办法,万一遇到紧急情况,你极有可能为你之前的储蓄而感到欣慰。
拯救非洲癌症患者
0=false
需要德语技能的工作也在2016年的第三季度显著增长。那些想做德语翻译工作的人或许近来很幸运。

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

福布斯杂志本周二发布全球收入最高女星排行榜,《饥饿游戏》女星詹妮弗-劳伦斯连续第二年蝉联榜首,收入约为4600万美元。排名第二的是著名美国谐星梅丽莎?麦卡西。

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

plat平坦+form形状→形状平的地方→平台,月台

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

"How many patients do Chinese doctors see a day? It can be more than 50," he told China Daily. "How can we have the time and energy to do research or publish papers?"
While Switzerland’s University of St Gallen retains the top spot, French and British business schools, with 24 and 18 programmes respectively, are the backbone of the 2017 FT ranking of 95 programmes around the world. More than half of UK schools move up the ranking, compared with one in France. A third of British schools rise five places, in contrast to the two-thirds of French schools that drop five or more places.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

仲量联行国际住宅物业服务公司副董事马克·艾略特在接受CNN采访时表示:“香港是一个有着700万人口的小岛。边界那边(中国大陆)有15亿人口想要在此投资。虽然政府正在腾出越来越多的土地,但是这并不管用。”
Good luck, good health, hood cheer. I wish you a happy New Year.

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

Maddie is so well recognised these days that a trip to Topshop results in her being mobbed by screaming tween fans who all want a selfie with their idol - something that has been tough to adjust to.
demo人民+-ic…的→民主的,民主主义的;民主政体的

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

WOLF HALL (PBS, April 5) In the season’s most promising piece of casting, Damian Lewis (“Homeland”) will play Henry VIII and the two-time Tony Award winner Mark Rylance will play Thomas Cromwell in this “Masterpiece” adaptation of the popular Hilary Mantel historical novels.
Widely misunderstood as a biopic about the novelist David Foster Wallace, Mr. Ponsoldt’s film is a comedy of journalistic bad manners and a bitter, knowing satire of the machinery of literary fame. Jesse Eisenberg and Jason Segel use the conventions of the buddy movie to perfect a new subgenre: the frenemy film.
It is not hard to think of recent examples, from Hugo Chávez to Viktor Orban and Vladimir Putin.
进入2月以来,猛龙逐渐感到他们需要进行人员调整了:良好的开局已经被挥霍的差不多了,他们的防守不足以限制对手,他们在四号位有个巨大的漏洞,在凯尔-洛瑞即将成为自由球员之前,他们急迫的需要利用好他的巅峰期。

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

4.British people may seem to apologise a lot, but it doesn't quite mean the same thing here. In the UK, "I'm sorry" actually means either a) I didn't hear you; b) I didn't understand you; or c) I both heard and understood you, and I think you're an idiot.

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

9.Be Honest
这位微软公司创始人的净资产是860亿美元,而一年前则是750亿美元。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

“Nick is an exceptional product thinker,” Adam Cahan, Yahoo’s senior vice-president of mobile and emerging products, said. “He does represent a generational shift in the kinds of things he is thinking about and what it means to be truly mobile. That generation is not just mobile-first, they are mobile only. That’s a different point of view.”

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

制造业也救不了经济。

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

'I think South Korea has a very rigorous and narrow definition of beauty because we’re an ethnically homogenous society and everyone looks pretty much the same. It is also related to low self-esteem.
It's lightweight and rolls up easily for travel.
But national and racial identity were often conflated for the white majority. That identity felt to many white people like one of the most important pillars holding up their world — and now it seems under threat.
Meghan Markle

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

……又唱又跳,希望能得到工作。
对两者而言,反对派是敌人而非观点不同的同胞。
When you think of him, your heart would jump between fast and fast.
It is based on a survey of business schools and another of their alumni who graduated in 2013.
She added that because of economic conditions and anti-immigration sentiment in some Western countries, many Chinese students find it difficult to stay in those countries.

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

这晚,霉霉并没有参加这次颁奖典礼,虽然她提名最多。19岁的歌手Shaw表选突出,风头胜过了霉霉,在这场颁奖典礼上横扫众多奖项。
PRICE PER SQUARE FOOT: $310

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

East New York in Brooklyn will be the test case when the Department of City Planning presents initial recommendations early next year. After that, the rezoning process could begin for the neighborhood, among the city’s poorest. A proposal for west Flushing in Queens is next.

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
From the themed collection: 深化京鄂战略合作协议在京签署
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

Fair enough. Let's put the Kings in the “maybe” file. I'll drop the Nuggets in there, as well, as they are in basically the same place as a franchise, give or take some dysfunctional elements. The Wizards have to go in there, too, much as I am down on them at the moment.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

在弗丽达·詹尼尼(Frida Giannini)为古驰(Gucci)设计的很多时装秀上都可以看到这种理念,包括2014年秋冬的台布渐变色和A字皮裙;2013年春夏的粉色长款衬衫和褶饰女主人连衣裙;2009年春夏的披头士风格鲜艳裤套装和宽松束腰长裙。
然而,一位要求匿名的律师表示,Teach First人从事教学工作获得的经验和自主能力可能意味着,他们会对再次从一家机构的底层做起感到沮丧。
Jose's mother Inma Quesada told the El Pais daily that her son "wanted to buy instruments" for his band Los Salerosos (loosely translated as "The Salties"), in which he plays the trumpet.
“尽管我本质上是一名工程师和分析人员,但迄今为止我所做过的最重要的决定都与此无关,它们永远是基于直觉,”他去年在曾就读MBA的杜克大学(Duke University)对一名采访者表示。

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

挪威诺贝尔和平奖委员会星期五在奥斯陆做出这一宣布时说,这三位女士分享这次和平奖是因为她们“为女性的安全和女性全面参与和平建设工作的权利进行非暴力的奋斗。”
The lyrics are stupid, but who cares? Tom Jones sings like nobody's business, and pounds the theme to Thunderball out with a silky energy. It's powerful but alluring. This is the sort of song you imagine Bond would play on a jukebox when he's about to seduce you. There are better James Bond theme songs, but none from a male singer. Tom Jones and James Bond probably go out for dry martinis together all the time. They're the perfect pair.
Zhang's piece is “so lush and so rich and so full and so complete,” Google Doodle team leader Ryan Germick told the Washington Post. “Every leaf seemed to have life in it.”
在本届戛纳电影节上,女性电影制作人以及相关女性话题曾广受关注成为宣传主题。28年来,戛纳首次以女导演拍摄的电影拉开序幕,伊莎贝拉?罗西里尼(Isabella Rossellini)成为“一种关注”单元评审团主席,莎尔玛?海雅克(Salma Hayek)主持讨论会高调探讨女性角色在电影中的意义。可以讨论的话题有许多,但是真的有何改变吗?数字似乎更能说明问题,主竞赛单元的19部入围作品仅有2部来自女性导演。而后发生的“高跟鞋门”,更有.....面对外界对于影展涉嫌性别歧视的负面消息,艺术总监蒂埃里?弗雷莫(Thierry Frémaux)一点儿反应都没。他只是说,戛纳电影节的举办有着及其不公平的高标准,参展影片不能申请其他诸如威尼斯或柏林电影节。这难道是建议人们去“攻击奥斯卡”?

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

The first is to view Asia as a market that has proved resistant to rapid development and will require significant structural and regulatory change before taking off. The second sees the possibility of sudden upside surprise.
Bursts of color are instant energy suppliers. If you can, paint your walls or use furniture and accessories to provide a colorful oomph.

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
From the themed collection: 高库存导致个别陶瓷产品跌幅超15%
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

《华盛顿邮报》
科森重塑了卡瑞尔的鼻子,把它变成鹰钩鼻。他还把卡瑞尔的发际线往后刮了一点,留出更多额头。
The findings of the US and UK scientists are based on thousands of global temperature measurements taken daily on land and at sea.
根据贝克?麦坚时国际律师事务所(Baker & McKenzie)和荣鼎咨询(Rhodium Group)的一份报告,2015年中国国有企业和民营企业在欧洲(包括挪威和瑞士,以及欧盟)总共投资了230亿美元,创历史新高;在美国投资了150亿美元。
待售房产:一栋带有三间卧室和三间半浴室的河滨当代住宅

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

New York City, now ranked seventh, has gone up 15 places since last year. It has seen a big jump in costs over recent years, moving up 42 spots since 2011.
《发生什么了,西蒙妮小姐?》(What Happened, Miss Simone?),导演:利兹·加布斯(Liz Garbus)。
The remaining of the top 10 were the University of Luxembourg (second), Ecole Polytechnique Federale de Lausanne (fourth), University of Geneva (fifth), ETH Zurich - Swiss Federal Institute of Technology Zurich (seventh), University of St. Gallen (eighth), National University of Singapore (ninth) and Imperial College London (10th).

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

The report didn't comment on potential factors influencing the numbers, but many – including members of the opposing political party – are laying the blame squarely at the feet of government cost-cutting.
2.Batman vs Superman: Dawn of Justice

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
From the themed collection: 六大基建新任务利好建材业
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

凯洛格/香港科大EMBA项目的优势在于学员的素质。
单词extend 联想记忆:
Ninety percent of the students believe their universities' guidance on entrepreneurship would help their future businesses. In addition, they professed appreciation for policies intended to encourage entrepreneurship.

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
From the themed collection: 楼市调控要推动形成合作博弈
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

“他随和、真诚、亲切,”IBM首席执行官罗睿兰(Ginni Rometty)说,并赞赏他“非常本真。这是现代CEO的特质。所见即所得。”
“We weren’t looking to throw the bums out, as they might say about an election. We were just really impressed with a flood of new powertrains, ” says Drew Winter, WardsAuto World Editor-in-Chief. “What was great yesterday might be less impressive tomorrow because engine technology is changing so rapidly.”
数据显示,在欧洲外的最受游客欢迎20大目的地中,游客的消费主要用于购物,而非就餐。尽管其中很多是世界著名的美食之都。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

*喜剧类最佳客串男演员:彼得?斯科拉里(Peter Scolari),《都市女孩》(Girls)

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

3. Economy is already crashing, GDP will get even worse in 2014-2016

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

Gitanjali表示,她想要进一步改善改设备,这样它最终就能进入市场了。
源于:prim(adj 整洁的;最好的;早的)

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

Entrepreneurs are movers and shakers. They can’t afford to analyze every detail or they’d never get anywhere. There is no place for procrastination in a startup. It’s a 24/7, no-vacation-or-sick-days kind of job that demands constant forward momentum. Make a brief assessment at every step and move on it. Trust your instincts.
8.Form or Join a Study Group
国家卫生健康委员会补充称,其中81.8%的新病例是同性恋行为造成的,这是由于学生“尽管对疾病有很高的认识,但对保护的意识不强”。
The report said families back home receive an average of $200 a month, which makes up 60 percent of the household income.Using the steady flow of remittances, families can buy food, get housing, go to school, access healthcare, improve sanitation, or even invest in a business and have some savings, the report said.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

单词creative 联想记忆:
With the Russian rouble depreciating against other major currencies, there has been an increase in visitors to this country in recent years.

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

6. Gene therapy comes good.
在2010年世界杯中,智利当属最振奋人心的一支队伍,并在最近的温布利比赛中让英格兰队在赛场上四处兜转,不过,如果哥伦比亚队能够融合射手拉达梅尔·法尔考(Radamel Falcao),那么这支队可能会让一两支队伍神伤了。因此,在所有的南美洲球队中,似乎只有厄瓜多尔难以走出小组赛,而其余的所有国家都有能力奋战到后面的阶段。

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

11月初,中国政府要求一些通过离岸实体操作的境外收购需得到监管部门批准,进一步收紧了对境外投资的管控。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

The Magic are the single-most mystifying team in this entire exercise. They make little sense on paper or on the court.
How the longer maternity leave policy is implemented is up to local governments to decide. Specific and legally-binding measures should be worked out at the national level to ensure the policy is carried out and properly enforced to ensure that women are not discriminated against by employers obsessed with minimizing their labor costs.
达福目前可能是最佳男配角的领跑者。
与此同时,前第五届和声明星 Camila Cabello证明了她的独唱生涯正在起飞,因为她的首张单曲《Havana》获得了最佳流行音乐奖。她的胜利意味着Taylor Swift失去了另一个奖项,尽管这对于歌手来说只是众多收获中的一个,但是近期她因为一年的沉寂过后又重新成为焦点。

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
From the themed collection: LG欲做全球最大OLED为主面板生产线
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

So, yeah, I think they should tank and they might even be able to get some good value for Ibaka in a trade even if it would be a really quick about-face. God they're weird.
['greisf?l]

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

“An employee sent his boss a text message to say he was leaving.”
28 June
“同为南方的儿子和疯狂的体育迷,我向你脱帽致敬,”前美国总统比尔?克林顿(Bill Clinton)发了一条推特(tweet)回应库克的文章。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

But the young boy still had on last trick up his sleeve before surrendering.
It's the summer of 1983, and precocious 17-year-old Elio Perlman is spending the days with his family at their 17th-century villa in Lombardy, Italy. He soon meets Oliver, a handsome doctoral student who's working as an intern for Elio's father. Amid the sun-drenched splendor of their surroundings, Elio and Oliver discover the heady beauty of awakening desire over the course of a summer that will alter their lives forever.
9.Be Honest

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

Bank of China followed the trend, with profits up only 1.3 per cent and ROAA declining by 0.1 percentage points.
allure

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
From the themed collection: 摇号前,一楼盘31组客户被剔除
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
From the themed collection: 中国瓷砖行业路在何方
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

14. 另一方面。下面是一份今年大制片公司发行,由女导演执导的粗略名单:华纳兄弟五部!包括拉娜·沃卓斯基(Lana Wachowski)、安妮·弗莱彻(Anne Fletcher)、黛娜·纳彻曼(Dana Nachman)、南希·迈耶斯(Nancy Meyers)和派翠西亚·莱根(Patricia Riggen)。环球影业三部,包括萨姆·泰勒·约翰逊(Sam Taylor Johnson)、伊丽莎白·班克斯(Elizabeth Banks)和安吉丽娜·朱莉(Angelina Jolie);迪斯尼一部,尼基·卡罗(Niki Caro)。派拉蒙零部。福克斯零部。索尼零部。我没有把福克斯和索尼的独立部门包括进去。
Hurricane Irma
In response to the incident, Jiedaibao made an announcement on its Sina Weibo on Dec. 1, stressing that the use of nude pictures as collateral for loans constitutes a private deal between users, which the company cannot regulate.

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

受此影响,对设备等关键领域的商业投资一直处在美国复苏历史中的低点。若就业市场缓慢改善,且家庭财富增长,则可能引发消费支出增加的良性循环,增强商业信心并增加投资。但若情况并非如此,那么今年将再度令人失望。
According to the index, tourists are "spending overwhelmingly" to shop -- and not to dine -- in the top 20 destinations outside of Europe, despite many of them being world-famous cuisine capitals.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

China's online retail volume is expected to outperform the rest of the world by reaching four trillion yuan (618 billion USdollars) this year, Commerce Minister Gao Hucheng said Sunday.
At the same time, college graduates' interest in further education has also dwindled, leading to an increase in students wanting employment from 71.2 percent last year to 75.6 percent this year. Nearly 30 percent of those graduates accepted offers from the internet industry, which is among the highest paying.
9、《神奇动物在哪里》

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
From the themed collection: 金砖会晤将给石材行业带来什么?
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

对于该行业规模有多大,众说纷纭,但高盛(Goldman Sachs)的数据表明,在2012至2014年期间,该行业的贷款规模从60亿元人民币增长至830亿元。

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
From the themed collection: 儿童家纺产品 品牌少价格高
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

报道称,代理商和投资机构正纷纷涌入该行业,对世界上第二大经济体的平台造成了额外改变。
Be prepared to save his life on numerous occasions.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

10. Deepika Padukone - $10 million
Allow me to congratulate you on the arrival of the New Year and to extend to you all my best wishes for your perfect health and lasting prosperity.

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
From the themed collection: 12月2日成都公积金延时服务暂停
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

[dr?ft]
“这部电影讲述的是在荒野中求生存、适应自然以及人文精神的胜利,更重要的主题是信任。”

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
From the themed collection: 雷士照明阎焱或将退出董事会
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

乔布斯在苹果平板电脑发布会上展示iPad,2010年1月,旧金山
Consider:

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

Consumers in many parts of the world have a preference for buying local which has helped boost the value of local brands.

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

Global emissions of greenhouse gases jumped 2.3 percent in 2013 to record levels, scientists reported Sunday, in the latest indication that the world remains far off track in its efforts to control global warming.
其中,国产动作片《战狼2》位居榜首,成了中国史上收入最高的影片,门票销售狂揽56.8亿元。
I'm only a child yet I know we are all part of a family, five billion strong, in fact, 30 million species strong and we all share the same air, water and soil -- borders and governments will never change that. 我只是一个小孩,但我知道我们都是一个大家庭的成员,超过60亿人的大家庭,以及超过三千万物种的大家庭,政府和国界永远都无法改变这个事实。
白人焦虑推动了今年的西方政治动荡:英国令人震惊地投票决定退出欧盟,美国的唐纳德?J?特朗普(Donald J. Trump)出人意料地获得了共和党的总统提名,挪威、匈牙利、奥地利和希腊的右翼民族主义崛起。

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

How are your competitors getting found online? Google Adwords Keyword Planner helps you answer this question. The word “Adwords” may give some ‘treps pause, as it sounds like you will have to purchase advertising. Not true. Google has made its Keyword Planner tool available to anyone with a Google account (you must first click through the Adwords entry portal). Use the Adwords Keyword Planner to see what keywords are generating the most search volume in your niche and identify opportunities to capture traffic.

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

v. 使防备,支撑,拉紧,使绷紧
2016年,我们看到很多新设备加入互联网(不幸的是,我们也看到他们被黑客打倒了大片)。从家用电器到服装,公司很想出售一些能使你的生活“智能化”的产品,但有时反而会适得其反。让我们来回顾在过去的一年里出现的一些最荒谬和最无用的互联网连接设备。
自2014年10月以来,新兴市场出口额(以美元计算)一直下降,即使没有2008年至2009年全球金融危机期间的下降幅度极端,也比当时持续的时间要长得多,如第一张图表所示。

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

Chinese Premier Li Keqiang said the economy performed better than forecast in 2017 and expects annual gross domestic product growth of around 6.9 per cent, according to state media.
●"Florida man dies in meth-lab explosion after lighting farts on fire"

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
From the themed collection: 加装电梯 广州将考虑补贴
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

去年我国内地人口总数达13.7亿,与2010年进行人口普查时相比,人口数量增加了3377万,这意味着人口年增长率为0.5%。
7.摩洛哥

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

卓越雇主排名:1

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

在进行融资时,约40%的创业者并未寻求任何外部帮助。他们中的半数完全依靠自己的积蓄及(或者)家人和朋友的资助,相比之下,只有40%的创业者向学校或校友网络寻求帮助。
Latest ECB projections predict the eurozone, which has struggled to grow as strongly as the US or UK, will grow 1.7 per cent in 2016 after hitting 1.5 per cent growth this year as QE bolsters the economy.
它有力地提醒我们,性革命、女性进入职场、消费主义的盛行以及太空时代都有阴暗的一面,有些人在其中受到了伤害。这是该剧具有强大影响力的一个原因。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

Despite the reported success of the Duke and Duchess of Cambridge's official visit to Canada back in September, timekeeping needs to be looked at for future trips.
After her legal travails , anything Kesha released would have a veneer of triumph. But this comeback set was an artistic warrior cry more potent than any might've expected.
截至德葡之战,本届世界杯已经结束了12场比赛,场均进球3.42个。预计尼日利亚对阵伊朗的比赛进球数将拉低这个统计,不过,只要本场比赛或随后的美加之战能够斩获至少一球,世界杯就会迎来场均进球三粒的第六天。历史上,平均达到如此进球数的还要追溯到1958年瑞典世界杯,也是贝利横空出世的一届。其中,12支球队在仅仅35场比赛中,场均进球3.6个。
据国家统计局上周三发布的调查显示,去年,我国人口总数有所增长,且男女性别比例及国民受教育程度均有所改善。

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

Writing for a Variety Special: Patton Oswalt, “Patton Oswalt: Talking for Clapping”
Until now, testing reliably for lead was expensive and meant sending away samples for analysis.

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

4. "The Big Bang Theory" (3.4 million)
What’s more, a Fiat engine not only places among Wards’ top 10 for the first time, it’s for an electric motor, the 83-kW unit found under the hood of the diminutive 500e. Unfortunately the car is only sold in California, though market forces might convince the automaker to send it into wider distribution should gas prices gain spike up to the $4.00/gallon mark or above.
超级大坏蛋们将受命保护人类——这就是《自杀小队》的主旨。 一个名叫“A.R.G.U.S”的政府机构招募了一些罪犯帮它执行危险任务,罪犯们将得到的报酬是减刑。这支特遣小队的成员有小丑、死亡射手、哈利·奎恩、回旋镖队长、杀人鳄以及DC漫画宇宙里的其他坏家伙。

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
From the themed collection: 北京54.79亿元扶贫资金拨付到位
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The data was released to encourage the adoption of stronger passwords. Mr Slain added:"As always, we hope that with more publicity about how risky it is to use weak passwords, more people will start taking simple steps to protect themselves by using stronger passwords and using different passwords for different websites."
v. 擦亮,磨

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